3 March 2014 The development of a simplified epithelial tissue phantom for the evaluation of an autofluorescence mitigation algorithm
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Abstract
Previously we developed an ultrathin, flexible, multimodal scanning fiber endoscope (SFE) for concurrent white light and fluorescence imaging. Autofluorescence (AF) arising from endogenous fluorophores (primarily collagen in the esophagus) act as major confounders in fluorescence-aided detection. To address the issue of AF, a real-time mitigation algorithm was developed and has been show to successfully remove AF during SFE imaging. To test our algorithm, we previously developed flexible, color-matched, synthetic phantoms featuring a homogenous distribution of collagen. In order to more rigorously test the AF mitigation algorithm, a phantom that better mimicked the in-vivo distribution of collagen in tissue was developed.
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Vivian W. Hou, Vivian W. Hou, Chenying Yang, Chenying Yang, Leonard Y. Nelson, Leonard Y. Nelson, Eric J. Seibel, Eric J. Seibel, } "The development of a simplified epithelial tissue phantom for the evaluation of an autofluorescence mitigation algorithm", Proc. SPIE 8945, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI, 894506 (3 March 2014); doi: 10.1117/12.2040167; https://doi.org/10.1117/12.2040167
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