4 March 2014 Development of a spectrally resolved fluorescence tomography system using a NIR swept laser and a digital micromirror array based detection system
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Abstract
We developed a spectrally-resolved fluorescence tomography (FT) system using a new source and detection unit. On the source side, we utilized a near-infrared (NIR) swept laser-based technology and on the detection side, we developed a digital micromirror device (DMD) based spectrally-resolved detection unit. We demonstrated the development of a NIR swept laser centered at 800 nm for FT, which covers the maximum absorption wavelength of a NIR fluorescence dye, indo-cyanine green (ICG) in plasma. Two different ICG samples whose absorption characteristics were slightly different were used to demonstrate the performance of the NIR swept laser-based FT system, and this FT system was able to show the difference of absorption between the ICG samples. In addition, we also developed a prototype spectrally-resolved detection unit based on the DMD. This detection system provided a spectral resolution of 15 nm and the possibility of simultaneous detection of multiple fluorescence spectra.
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Jaedu Cho, Jaedu Cho, Seung Woan Jeon, Seung Woan Jeon, Jie Zheng, Jie Zheng, Chang-Seok Kim, Chang-Seok Kim, Orhan Nalcioglu, Orhan Nalcioglu, Gultekin Gulsen, Gultekin Gulsen, } "Development of a spectrally resolved fluorescence tomography system using a NIR swept laser and a digital micromirror array based detection system", Proc. SPIE 8947, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, 89470Z (4 March 2014); doi: 10.1117/12.2041151; https://doi.org/10.1117/12.2041151
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