4 March 2014 10×10-pixel 606kS/s multi-point fluorescence correlation spectroscopy CMOS image sensor
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Abstract
To observe molecular transport in a living cell, a high-speed CMOS image sensor for multi-point fluorescence correlation spectroscopy is developed. To achieve low-noise and high-speed simultaneously, a prototype CMOS image sensor is designed based on a complete pixel-parallel architecture and multi-channel pipelined pixel readout. The prototype chip with 10×10 effective pixels is fabricated in 0.18-μm CMOS image sensor technology. The pixel pitch and the photosensitive area are 56μm and 10μm in diameter without a microlens, respectively. In the experiment, the total sampling rate of 606kS/s is achieved. The measured average random noise is 24.9LSB, which is equivalent to about 2.5 electrons in average.
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Keiichiro Kagawa, Keiichiro Kagawa, Taishi Takasawa, Taishi Takasawa, Zhang Bo, Zhang Bo, Min-Woong Seo, Min-Woong Seo, Kaita Imai, Kaita Imai, Jotaro Yamamoto, Jotaro Yamamoto, Masataka Kinjo, Masataka Kinjo, Susumu Terakawa, Susumu Terakawa, Keita Yasutomi, Keita Yasutomi, Shoji Kawahito, Shoji Kawahito, } "10×10-pixel 606kS/s multi-point fluorescence correlation spectroscopy CMOS image sensor", Proc. SPIE 8947, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, 894713 (4 March 2014); doi: 10.1117/12.2041131; https://doi.org/10.1117/12.2041131
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