28 February 2014 A novel clinical multimodal multiphoton tomograph for AF, SHG, CARS imaging, and FLIM
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Abstract
We report on a flexible nonlinear medical tomograph with multiple miniaturized detectors for simultaneous acquisition of two-photon autofluorescence (AF), second harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) images. The simultaneous visualization of the distribution of endogenous fluorophores NAD(P)H, melanin and elastin, SHG-active collagen and as well as non-fluorescent lipids within human skin in vivo is possible. Furthermore, fluorescence lifetime images (FLIM) can be generated using time-correlated single photon counting.
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Martin Weinigel, Hans Georg Breunig, Karsten König, "A novel clinical multimodal multiphoton tomograph for AF, SHG, CARS imaging, and FLIM", Proc. SPIE 8948, Multiphoton Microscopy in the Biomedical Sciences XIV, 89481R (28 February 2014); doi: 10.1117/12.2037652; https://doi.org/10.1117/12.2037652
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