28 February 2014 A novel clinical multimodal multiphoton tomograph for AF, SHG, CARS imaging, and FLIM
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We report on a flexible nonlinear medical tomograph with multiple miniaturized detectors for simultaneous acquisition of two-photon autofluorescence (AF), second harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) images. The simultaneous visualization of the distribution of endogenous fluorophores NAD(P)H, melanin and elastin, SHG-active collagen and as well as non-fluorescent lipids within human skin in vivo is possible. Furthermore, fluorescence lifetime images (FLIM) can be generated using time-correlated single photon counting.
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Martin Weinigel, Martin Weinigel, Hans Georg Breunig, Hans Georg Breunig, Karsten König, Karsten König, } "A novel clinical multimodal multiphoton tomograph for AF, SHG, CARS imaging, and FLIM", Proc. SPIE 8948, Multiphoton Microscopy in the Biomedical Sciences XIV, 89481R (28 February 2014); doi: 10.1117/12.2037652; https://doi.org/10.1117/12.2037652


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