12 March 2014 Full field photothermal dynamics microscopy
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We present here a novel full field pump-probe photothermal dynamics microscopy (PTDM) which uses a numerical lockin mechanism for capturing full field photothermal responses and is capable of imaging 2D thermal dissipation dynamics by varying the time delay between the probing and pump nano-second pulses. PTDM may find interesting applications in biology and medicine. As one example, we report PTDM imaging nuclei contained on intact hematoxylin and eosin (H&E) stained prostate cancer specimens may potentially be used to distinguish low grade and high grade prostate cancer.
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Guichen Tang, Guichen Tang, Fanting Kong, Fanting Kong, Y. C. Chen, Y. C. Chen, M. Xu, M. Xu, "Full field photothermal dynamics microscopy", Proc. SPIE 8949, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXI, 89490X (12 March 2014); doi: 10.1117/12.2042326; https://doi.org/10.1117/12.2042326

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