28 February 2014 A demonstration of multiplex biosensing using whispering gallery mode microspheres positioned onto a microstructured optical fiber tip
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Abstract
Here, we show that multiplexed Whispering Gallery Modes sensing can be achieved using two dye-doped microspheres positioned onto the tip of a Microstructured Optical Fiber. By operating the dye-doped microspheres below their lasing threshold, the individual resonances of each sphere overlap and therefore cannot be distinguished. However, when excited above their lasing threshold results in a de-convoluted spectrum where the resonances belonging to the individual spheres can be determined, enabling the detection of a specific interaction in one resonator and using the second as a dynamic reference, or monitoring different specific interactions with both spheres.
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T. Reynolds, A. François, S. J. Nicholls, T. M. Monro, "A demonstration of multiplex biosensing using whispering gallery mode microspheres positioned onto a microstructured optical fiber tip ", Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 895110 (28 February 2014); doi: 10.1117/12.2039328; https://doi.org/10.1117/12.2039328
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