High-speed dual-wavelength optical polarimetry for glucose sensing

Daniel T. Grunden; Casey W. Pirnstill; Gerard L. Coté

doi:10.1117/12.2040239

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28 February 2014 High-speed dual-wavelength optical polarimetry for glucose sensing

Daniel T. Grunden, Casey W. Pirnstill, Gerard L. Coté

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Proceedings Volume 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics; 895111 (2014) https://doi.org/10.1117/12.2040239
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Optical polarimetry in the anterior chamber of the eye has emerged as a potential technique to non-invasively measure glucose levels for diabetes. Time varying corneal birefringence due to eye motion artifact confounds the optical signal ultimately limiting the polarimetric technique from accurately predicting glucose concentrations. In this study, a high speed dual-wavelength optical polarimetric approach was developed and in vitro phantom studies were performed with and without motion. The glucose concentrations ranged from 0-600 mg/dL at 100 mg/dL increments. The polarimeter produced glucose measurements with less than a 10 msec stabilization time and yielding standard errors of less than 10 mg/dL without motion and standard errors less than 26 mg/dL with motion. The results indicate a high speed dual-wavelength polarimetric approach has the potential to be used for non-invasive glucose measurements.

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Daniel T. Grunden, Casey W. Pirnstill, and Gerard L. Coté "High-speed dual-wavelength optical polarimetry for glucose sensing", Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 895111 (28 February 2014); https://doi.org/10.1117/12.2040239

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