28 February 2014 Multimodal assessment of spatial distribution of drug-tracer uptake by brain tissue after intra-arterial injections
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Abstract
It is challenging to track the rapid changes in drug concentrations after intra-arterial (IA) administration to elucidate the pharmacokinetics of this method of drug delivery. Traditional pharmacokinetic parameters (such as protein binding) that are highly relevant to intravenous (IV) administration do not seem to apply to IA injections. Regional drug delivery is affected by the biomechanics of drug injection, resting blood flow, and local tissue extraction. In-vivo and ex-vivo, optical methods for spatial mapping of drug deposition can assist in visualizing drug distributions and aid in the screening of potential drugs and carrier candidates. We present a multimodal approach for the assessment of drug distribution in postmortem tissue specimens using diffuse reflectance spectroscopy, multispectral imaging, and confocal microscopy and demonstrate feasibility of distinguishing route of administration advantages of liposome-dye conjugate delivery. The results of this study suggest that insight on drug dynamics gained by this aggregated approach can be used to help screen and/or optimize potential drug candidates and drug delivery protocols.
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Rajinder Singh-Moon, Durba Chaudhuri, Mei Wang, Robert Straubinger, Irving J. Bigio, Shailendra Joshi, "Multimodal assessment of spatial distribution of drug-tracer uptake by brain tissue after intra-arterial injections", Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 895113 (28 February 2014); doi: 10.1117/12.2040634; https://doi.org/10.1117/12.2040634
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