4 March 2014 Binge consumption of ethanol during pregnancy leads to significant developmental delay of mouse embryonic brain
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Abstract
Consumption of alcohol during pregnancy can be severely detrimental to the development of the brain in fetuses. This study explores the usage of optical coherence tomography (OCT) to the study the effects of maternal consumption of ethanol on brain development in mouse fetuses. On gestational day 14.5, fetuses were collected and fixed in 4% paraformaldehyde. A swept-source OCT (SSOCT) system was used to acquire 3D images of the brain of ethanol-exposed and control fetuses. The volume of right and left brain ventricles were measured and used to compare between ethanol-exposed and control fetuses. A total of 5 fetuses were used for each of the two groups. The average volumes of the right and left ventricles were measured to be 0.35 and 0.15 mm3 for ethanol-exposed and control fetuses, respectively. The results demonstrated that there is an alcohol-induced developmental delay in mouse fetal brains.
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Narendran Sudheendran, Narendran Sudheendran, Shameena Bake, Shameena Bake, Rajesh C. Miranda, Rajesh C. Miranda, Kirill V. Larin, Kirill V. Larin, } "Binge consumption of ethanol during pregnancy leads to significant developmental delay of mouse embryonic brain", Proc. SPIE 8953, Optical Methods in Developmental Biology II, 89530D (4 March 2014); doi: 10.1117/12.2045528; https://doi.org/10.1117/12.2045528
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