Enhanced coherent anti-Stokes Raman scattering imaging using silica mircospheres

X. Huang; X. N. He; W. Xiong; Y. Gao; L. J. Jiang; L. Liu; Y. S. Zhou; J. F. Silvain; L. Jiang; Y. F. Lu

doi:10.1117/12.2041783

20 February 2014 Enhanced coherent anti-Stokes Raman scattering imaging using silica mircospheres

X. Huang, X. N. He, W. Xiong, Y. Gao, L. J. Jiang, L. Liu, Y. S. Zhou, J. F. Silvain, L. Jiang, Y. F. Lu

Proceedings Volume 8954, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI; 895402 (2014) https://doi.org/10.1117/12.2041783
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

A technique was developed to achieve enhanced coherent anti-Stokes Raman scattering (CARS) imaging using selfassembled silica microspheres. In this study, a layer of optically transparent silica microspheres was self-assembled onto polymer grating samples to enhance the CARS signals. The highest enhancement of 12.5 was achieved using 6.1-μmdiameter microspheres for C-H molecule vibration. Finite-difference time-domain (FDTD) algorithm under the perfectly matched layer boundary condition was used to simulate the enhancement using silica microspheres of different diameters.

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X. Huang, X. N. He, W. Xiong, Y. Gao, L. J. Jiang, L. Liu, Y. S. Zhou, J. F. Silvain, L. Jiang, and Y. F. Lu "Enhanced coherent anti-Stokes Raman scattering imaging using silica mircospheres", Proc. SPIE 8954, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI, 895402 (20 February 2014); https://doi.org/10.1117/12.2041783

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