20 February 2014 Symmetries and biology: a new approach to biosensing
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Abstract
We propose a novel detection method based on the symmetry breaking induced by the bio-molecule to be detected. Briefly, by choosing a sensor presenting a particular symmetry, the revolution symmetry, the adsorption of an analyte will break this symmetry. By detecting this change in the symmetries of the system, the presence of bio-molecules can be detected. This optical method provides substantial advantages over current approaches for the conception of biosensors. In particular, this approach relies on geometrical considerations, providing important properties such as the possibility to multiplex spatially or in wavelength. In addition, it relaxes strongly the constrains on the sensor as no specific plasmon resonances are necessary. We believe this work opens promising alternatives for the development of biosensors.
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M. L. Juan, M. L. Juan, X. Vidal, X. Vidal, G. Molina-Terriza, G. Molina-Terriza, } "Symmetries and biology: a new approach to biosensing", Proc. SPIE 8954, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI, 89540I (20 February 2014); doi: 10.1117/12.2038863; https://doi.org/10.1117/12.2038863
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