20 February 2014 Polymer slab waveguides for the optical detection of nanoparticles in evanescent field based biosensors
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Abstract
We present a polymer optical waveguide integration technology for the detection of nanoparticles in an evanescent field based biosensor. In the proposed biosensor concept, super-paramagnetic nanoparticles are used as optical contrast labels. The nanoparticles capture target molecules from a sample fluid and bind to the sensor surface with biological specificity. The surface-bound nanoparticles are then detected using frustration of an evanescent field. In the current paper we elaborate on the polymer waveguides which are used to generate a well-defined optical field for nanoparticle detection.
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Nuria Teigell Beneitez, Nuria Teigell Beneitez, Jeroen Missinne, Jeroen Missinne, Jean Schleipen, Jean Schleipen, Joke Orsel, Joke Orsel, Menno W. J. Prins, Menno W. J. Prins, Geert Van Steenberge, Geert Van Steenberge, } "Polymer slab waveguides for the optical detection of nanoparticles in evanescent field based biosensors", Proc. SPIE 8954, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI, 89540Q (20 February 2014); doi: 10.1117/12.2036072; https://doi.org/10.1117/12.2036072
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