Lipid-modified dendrimers as a tool for the design of nanoparticle-based multimodal MRI contrast agents

Adriano Boni; Mauro Gemmi; Claudia Innocenti; Giuseppe Bardi; Alice Bertero; Giovanni Signore; Angelo Bifone

doi:10.1117/12.2036748

24 March 2014 Lipid-modified dendrimers as a tool for the design of nanoparticle-based multimodal MRI contrast agents

Adriano Boni, Mauro Gemmi, Claudia Innocenti, Giuseppe Bardi, Alice Bertero, Giovanni Signore, Angelo Bifone

Proceedings Volume 8955, Colloidal Nanoparticles for Biomedical Applications IX; 895502 (2014) https://doi.org/10.1117/12.2036748
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

A fast and easy method for water transfer of iron oxide nanoparticle based on the hydrophobic interaction of oleic acid coated nanoparticles with the amphiphilic PAMAM-C12 dendrimer is described. The process may be conveniently performed in water and yields nanoparticles with good size distribution, diameter modulation and high crystallinity. The nanoparticles have been functionalized with gadolinium ions to obtain T₁/T₂ dual mode contrast agents. Furthermore, the possibility to deliver and release lipophilic drugs was investigated.

Citation Download Citation

Adriano Boni, Mauro Gemmi, Claudia Innocenti, Giuseppe Bardi, Alice Bertero, Giovanni Signore, and Angelo Bifone "Lipid-modified dendrimers as a tool for the design of nanoparticle-based multimodal MRI contrast agents", Proc. SPIE 8955, Colloidal Nanoparticles for Biomedical Applications IX, 895502 (24 March 2014); https://doi.org/10.1117/12.2036748

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available