7 March 2014 Ultrabright and bleaching-resistant hybrid gold nanoparticles for confocal and two-photon fluorecence imaging
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Abstract
We review our work on hybrid gold nanoparticles that are optimized for their bright fluorescence and photobleaching resistance. Our first goal in using gold nanoparticles is to load a large density of photoactive molecules onto a biocompatible nanoplatform. Our second goal is to optimize the molecule-gold nanoparticle interaction to improve the photoactive properties, in particular their photobleaching resistance. In this project gold nanoparticles have typical dimensions in the 50-100 nm that are suitable for in vivo imaging and photodynamic therapy. Their geometrical shapes include nanoshell, spheres, rods, bipyramids and stars.
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P. L. Baldeck, P. L. Baldeck, J. Navarro, J. Navarro, G. Micouin, G. Micouin, A.-M. Gabudean, A.-M. Gabudean, F. Lerouge, F. Lerouge, C. Monnerau, C. Monnerau, F. Chaput, F. Chaput, C. Andraud, C. Andraud, S. Parola, S. Parola, } "Ultrabright and bleaching-resistant hybrid gold nanoparticles for confocal and two-photon fluorecence imaging", Proc. SPIE 8956, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI, 89560T (7 March 2014); doi: 10.1117/12.2039479; https://doi.org/10.1117/12.2039479
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