5 March 2014 Microfabrication of curcumin-loaded microparticles using coaxial electrohydrodynamic atomization
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Abstract
Encapsulation of curcumin in PLGA microparticles is performed by a coaxial electrohydrodynamic atomization device. To optimize the process, the effects of different control parameters on morphology and size distribution of resultant microparticles are studied systemically. Four main flow modes are identified as the applied electric field intensity increases. The stable cone-jet configuration is found to be available for fabricating monodisperse microparticles with core-shell structures. The results are compared with those observed in traditional emulsion. The drug-loading efficiency is also checked. The present system is advantageous for the enhancement of particle size distribution and drug-loading efficiency in various applications such as drug delivery, biomedicine and image-guided therapy.
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Shuai Yuan, Ting Si, Zhongfa Liu, Ronald X. Xu, "Microfabrication of curcumin-loaded microparticles using coaxial electrohydrodynamic atomization", Proc. SPIE 8956, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI, 895618 (5 March 2014); doi: 10.1117/12.2041070; https://doi.org/10.1117/12.2041070
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