Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates

Anna Chiara De Luca; Peter Reader-Harris; Michael Mazilu; Stefano Managò; Stefania Mariggiò; Daniela Corda; Andrea Di Falco

doi:10.1117/12.2039697

3 March 2014 Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates

Anna Chiara De Luca, Peter Reader-Harris, Michael Mazilu, Stefano Managò, Stefania Mariggiò, Daniela Corda, Andrea Di Falco

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Proceedings Volume 8957, Plasmonics in Biology and Medicine XI; 895709 (2014) https://doi.org/10.1117/12.2039697
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithography. This device is used for glycerophosphoinositol (GroPIns) molecule sensing. GroPIns is an abundant component of cell cytosol and high GroPIns levels have been reported in several tumour cells. We demonstrate that our SERS sensor is able to accurately and quantitatively determine the concentration of GroPIns. These results indicate that SERS may provide a novel platform technology to identify GroPIns profiles in disease pathogenesis.

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Anna Chiara De Luca, Anna Chiara De Luca, Peter Reader-Harris, Peter Reader-Harris, Michael Mazilu, Michael Mazilu, Stefano Managò, Stefano Managò, Stefania Mariggiò, Stefania Mariggiò, Daniela Corda, Daniela Corda, Andrea Di Falco, Andrea Di Falco, "Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates", Proc. SPIE 8957, Plasmonics in Biology and Medicine XI, 895709 (3 March 2014); doi: 10.1117/12.2039697; https://doi.org/10.1117/12.2039697

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