6 March 2014 A newly designed optical biochip for a TDM-POCT device
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Abstract
The design of a novel therapeutic drug monitoring (TDM) point-of-care-testing (POCT) biochip for immunosuppressants detection in transplanted patients is described. The chip consists of two polymeric parts, a top PMMA slide and a bottom ZEONOR® thin foil, bonded together by means of a pressure sensitive adhesive tape. The tape, with lower refractive index, is shaped in order to obtain a microfluidic multi-channel array. The optical signal, coming from an external light source and travelling along the ZEONOR® thin foil, excites the fluorescent sensing layer immobilized onto the fluidic channels. Preliminary tests with the bioassay implementation for tacrolimus detection are reported.
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C. Berrettoni, C. Trono, S. Berneschi, A. Giannetti, S. Tombelli, R. Bernini, A. Grimaldi, G. Persichetti, G. Testa, L. Bolzoni, G. Porro, H. Becker, C. Gärtner, F. Baldini, "A newly designed optical biochip for a TDM-POCT device", Proc. SPIE 8976, Microfluidics, BioMEMS, and Medical Microsystems XII, 89760P (6 March 2014); doi: 10.1117/12.2042389; https://doi.org/10.1117/12.2042389
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