A newly designed optical biochip for a TDM-POCT device

C. Berrettoni; C. Trono; S. Berneschi; A. Giannetti; S. Tombelli; R. Bernini; A. Grimaldi; G. Persichetti; G. Testa; L. Bolzoni; G. Porro; H. Becker; C. Gärtner; F. Baldini

doi:10.1117/12.2042389

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6 March 2014 A newly designed optical biochip for a TDM-POCT device

C. Berrettoni, C. Trono, S. Berneschi, A. Giannetti, S. Tombelli, R. Bernini, A. Grimaldi, G. Persichetti, G. Testa, L. Bolzoni, G. Porro, H. Becker, C. Gärtner, F. Baldini

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Proceedings Volume 8976, Microfluidics, BioMEMS, and Medical Microsystems XII; 89760P (2014) https://doi.org/10.1117/12.2042389
Event: SPIE MOEMS-MEMS, 2014, San Francisco, California, United States

Abstract

The design of a novel therapeutic drug monitoring (TDM) point-of-care-testing (POCT) biochip for immunosuppressants detection in transplanted patients is described. The chip consists of two polymeric parts, a top PMMA slide and a bottom ZEONOR® thin foil, bonded together by means of a pressure sensitive adhesive tape. The tape, with lower refractive index, is shaped in order to obtain a microfluidic multi-channel array. The optical signal, coming from an external light source and travelling along the ZEONOR® thin foil, excites the fluorescent sensing layer immobilized onto the fluidic channels. Preliminary tests with the bioassay implementation for tacrolimus detection are reported.

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C. Berrettoni, C. Trono, S. Berneschi, A. Giannetti, S. Tombelli, R. Bernini, A. Grimaldi, G. Persichetti, G. Testa, L. Bolzoni, G. Porro, H. Becker, C. Gärtner, and F. Baldini "A newly designed optical biochip for a TDM-POCT device", Proc. SPIE 8976, Microfluidics, BioMEMS, and Medical Microsystems XII, 89760P (6 March 2014); https://doi.org/10.1117/12.2042389

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