A newly designed optical biochip for a TDM-POCT device

C. Berrettoni; C. Trono; S. Berneschi; A. Giannetti; S. Tombelli; R. Bernini; A. Grimaldi; G. Persichetti; G. Testa; L. Bolzoni; G. Porro; H. Becker; C. Gärtner; F. Baldini

doi:10.1117/12.2042389

6 March 2014 A newly designed optical biochip for a TDM-POCT device

C. Berrettoni, C. Trono, S. Berneschi, A. Giannetti, S. Tombelli, R. Bernini, A. Grimaldi, G. Persichetti, G. Testa, L. Bolzoni, G. Porro, H. Becker, C. Gärtner, F. Baldini

Author Affiliations +

Proceedings Volume 8976, Microfluidics, BioMEMS, and Medical Microsystems XII; 89760P (2014) https://doi.org/10.1117/12.2042389
Event: SPIE MOEMS-MEMS, 2014, San Francisco, California, United States

Abstract

The design of a novel therapeutic drug monitoring (TDM) point-of-care-testing (POCT) biochip for immunosuppressants detection in transplanted patients is described. The chip consists of two polymeric parts, a top PMMA slide and a bottom ZEONOR® thin foil, bonded together by means of a pressure sensitive adhesive tape. The tape, with lower refractive index, is shaped in order to obtain a microfluidic multi-channel array. The optical signal, coming from an external light source and travelling along the ZEONOR® thin foil, excites the fluorescent sensing layer immobilized onto the fluidic channels. Preliminary tests with the bioassay implementation for tacrolimus detection are reported.

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C. Berrettoni, C. Berrettoni, C. Trono, C. Trono, S. Berneschi, S. Berneschi, A. Giannetti, A. Giannetti, S. Tombelli, S. Tombelli, R. Bernini, R. Bernini, A. Grimaldi, A. Grimaldi, G. Persichetti, G. Persichetti, G. Testa, G. Testa, L. Bolzoni, L. Bolzoni, G. Porro, G. Porro, H. Becker, H. Becker, C. Gärtner, C. Gärtner, F. Baldini, F. Baldini, "A newly designed optical biochip for a TDM-POCT device", Proc. SPIE 8976, Microfluidics, BioMEMS, and Medical Microsystems XII, 89760P (6 March 2014); doi: 10.1117/12.2042389; https://doi.org/10.1117/12.2042389

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