6 March 2014 Monolithic optoelectronic chip for label-free multi-analyte sensing applications
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Abstract
The existing technological approaches employed in the realization of optical sensors still face two major challenges: the inherent inability of most sensors to integrate the optical source in the transducer chip, and the need to specifically design the optical transducer per application. We have introduced a unique Optoelectronic chip that consists of a series of light emitting diodes (LEDs) coupled to silicon nitride waveguides allowing for multi-analyte detection. Each optocoupler is structured as Broad-Band Mach-Zehnder Interferometer and has its own excitation source and can either have its own detector or the entire array can share a common detector. The light emitting devices (LEDs) are silicon avalanche diodes which when biased beyond their breakdown voltage emit in the VIS-NIR part of the spectrum. The optoelectronic chip is fabricated by standard silicon technology allowing for potential mass production in silicon foundries. The integrated nature of the optoelectronic chip and the ability to functionalize each transducer independently allows for the development of miniaturized optical transducers tailored towards multi-analyte tests. The platform has been successfully applied in bioassays and binding assays monitoring in a real-time and label-free format and is currently being applied to ultra-sensitive food safety applications.
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Ioannis Raptis, Ioannis Raptis, Eleni Makarona, Eleni Makarona, Panagiota Petrou, Panagiota Petrou, Sotiris E. Kakabakos, Sotiris E. Kakabakos, Konstantinos Misiakos, Konstantinos Misiakos, } "Monolithic optoelectronic chip for label-free multi-analyte sensing applications", Proc. SPIE 8976, Microfluidics, BioMEMS, and Medical Microsystems XII, 89760X (6 March 2014); doi: 10.1117/12.2041937; https://doi.org/10.1117/12.2041937
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