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30 January 2014 The optical origin of the PPG signal
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PPG volumetric model is frequently adopted to explain the pulsatile nature of optical response for arterial pulsation. In this article we show that the pulsatile fluctuation of optical response can be explained in terms of the light scattering related changes. According to this assumption, these fluctuations are driven by the modulation the scattering coefficient associated with the blood flow hemodynamic effects. There was shown that the proposed model yields a good correspondence with the pulse-oximetry related parameters. Moreover, it was found that the experimental relationship between the red blood concentration in the blood (hematocrit) and the parameters being derived from the in vivo measured optical signals can be described in terms of this scattering driven model. There was demonstrated that the commonly used volumetric assumption fails to provide a reasonable description of the experimental results. The last fact can be used as a decisive argument in favor of the scattering driven model. This model can be used for better understanding of the pulse oximetry as well as for the guidance for the algorithmic development of the blood hemoglobin/ hematocrit in vivo.
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I. Fine "The optical origin of the PPG signal ", Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 903103 (30 January 2014);

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