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30 January 2014 Simple numerical model of OCT signal evolution due to the diffusion of an optical clearing agent
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A simple numerical model is proposed to describe the process of OCT signal formation in a scattering medium (biological tissue) under the conditions of immersion chemical agent diffusion. Due to optical clearing of the tissue the shape of the OCT A-scan becomes time-dependent, thus providing information about the diffusion rate. The model includes the numerical solution of the diffusion equation, the relation between the concentration of clearing agent and the scattering coefficient, and, finally, the description of the OCT signal formation given the material parameters and with the probe beam geometry taken into account. The test calculations qualitatively reproduce the experimentally observed time behavior of A-scans in samples of human tooth dentine, caused by diffusion of different chemical agents. In particular, it is shown that the non-monotonic A-scans having a maximum can be explained by assuming that the backscattering coefficient giving rise to the OCT signal is, at least partially, subject to optical clearing alongside with the scattering coefficient responsible for the signal attenuation.
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Natalia A. Trunina, Vladimir L. Derbov, and Valery V. Tuchin "Simple numerical model of OCT signal evolution due to the diffusion of an optical clearing agent", Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 90310B (30 January 2014);

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