30 January 2014 In-vitro terahertz spectroscopy of rat skin under the action of dehydrating agents
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In the paper we present the results of study of rat skin and rat subcutaneous tumor under the action of dehydrating agents in terahertz (THz) range (15-30 THz). Frustrated Total Internal Reflection (FTIR) spectra were obtained with infrared Fourier spectrometer Nicolet 6700 and then they were recalculated in the transmittance spectra with Omnic software. Experiments were carried out with healthy and xenografted tumor in skin tissue in vitro. As the dehydrating agents 100% glycerol, 40%-water glucose solution, PEG-600, and propylene glycol were used. To determine the effect of the optical clearing agent (OCA), the alterations of terahertz transmittance for the samples were analyzed. The results have shown that PEG-600 and 40%-glucose water solution are the most effective dehydrating agent. The transmittance of healthy skin after PEG-600 application increased approximately by 6% and the transmittance of tumor tissue after PEG- 600 and 40%-glucose water solution application increased approximately by 8%. Obtained data can be useful for further application of terahertz radiation for tumor diagnostics.
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Aleksandr S. Kolesnikov, Aleksandr S. Kolesnikov, Ekaterina A. Kolesnikova, Ekaterina A. Kolesnikova, Daria K. Tuchina, Daria K. Tuchina, Artem G. Terentyuk, Artem G. Terentyuk, Maxim Nazarov, Maxim Nazarov, Alexander A. Skaptsov, Alexander A. Skaptsov, Alexander P. Shkurinov, Alexander P. Shkurinov, Valery V. Tuchin, Valery V. Tuchin, "In-vitro terahertz spectroscopy of rat skin under the action of dehydrating agents", Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 90310D (30 January 2014); doi: 10.1117/12.2052226; https://doi.org/10.1117/12.2052226

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