The impact of laser radiation on the photodissociation of carboxyhemoglobin  in blood

S. A. Mamilov; S S. Esman; D. V. Veligodski; M. M. Asimov; E. G. Borisova; A. I. Gisbrecht

doi:10.1117/12.2051398

30 January 2014 The impact of laser radiation on the photodissociation of carboxyhemoglobin in blood

S. A. Mamilov, S S. Esman, D. V. Veligodski, M. M. Asimov, E. G. Borisova, A. I. Gisbrecht

Proceedings Volume 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV; 90310G (2014) https://doi.org/10.1117/12.2051398
Event: Saratov Fall Meeting 2013, 2013, Saratov, Russian Federation

Abstract

This paper presents an experimental study in vivo of the rate of the carboxyhemoglobin (HbCO) photodissociation in blood under the influence of the transcutaneous laser irradiation in visible spectral range from 405 to 700 nm. Despite the similarity of the HbCO and HbO2 action spectra, the designed 3-wavelengths measurement system makes it possible to obtain reliable measuring of the HbCO decrease level. The results show that there is a relatively narrow spectral range in the visible region where one could effectively (up to 50%) dissociate carboxyhemoglobin in blood through the tissue. The obtained results can be used in clinical practice on phototherapy and for effective treatment of CO poisoning.

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S. A. Mamilov, S S. Esman, D. V. Veligodski, M. M. Asimov, E. G. Borisova, and A. I. Gisbrecht "The impact of laser radiation on the photodissociation of carboxyhemoglobin in blood", Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 90310G (30 January 2014); https://doi.org/10.1117/12.2051398

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KEYWORDS

Blood

Carbon monoxide

Oxygen

Absorption

Skin

Tissues

In vivo imaging

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