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19 March 2014 A new approach to regularized iterative CT image reconstruction
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Iterative image reconstruction gains more and more interest in clinical routine, as it promises to reduce image noise, to reduce artifacts, or to improve spatial resolution. Among vendors and researchers, however, there is no consensus of how to best achieve these aims. The general approach is to incorporate a priori knowledge into iterative image reconstruction for example by adding additional constraints to the cost function, which penalize strong variations between neighboring voxels. However this approach to regularization in general poses a resolution noise trade–off because the stronger the regularization, and thus the noise reduction, the stronger the loss of spatial resolution and thus loss of anatomical detail. We propose a method which tries to improve this trade-off. One starts with generating basis images, which emphasize certain desired image properties, like high resolution or low noise. The proposed reconstruction algorithm reconstructs voxel–specific weighting coefficients that are applied to combine the basis images. By combining the desired properties of each basis image one can generate an image with lower noise and maintained high contrast resolution thus improving the resolution noise trade–off.
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Christian Hofmann, Michael Knaup, and Marc Kachelrieß "A new approach to regularized iterative CT image reconstruction", Proc. SPIE 9033, Medical Imaging 2014: Physics of Medical Imaging, 90330R (19 March 2014);

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