19 March 2014 Phase contrast portal imaging for image-guided microbeam radiation therapy
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Abstract
High-dose synchrotron microbeam radiation therapy is a unique treatment technique used to destroy tumors without severely affecting circumjacent healthy tissue. We applied a phase contrast technique to portal imaging in preclinical microbeam radiation therapy experiments. Phase contrast portal imaging is expected to enable us to obtain higherresolution X-ray images at therapeutic X-ray energies compared to conventional portal imaging. Frontal view images of a mouse head sample were acquired in propagation-based phase contrast imaging. The phase contrast images depicted edge-enhanced fine structures of the parietal bones surrounding the cerebrum. The phase contrast technique is expected to be effective in bony-landmark-based verification for image-guided radiation therapy.
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Keiji Umetani, Keiji Umetani, Takeshi Kondoh, Takeshi Kondoh, "Phase contrast portal imaging for image-guided microbeam radiation therapy", Proc. SPIE 9033, Medical Imaging 2014: Physics of Medical Imaging, 90335P (19 March 2014); doi: 10.1117/12.2043216; https://doi.org/10.1117/12.2043216
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