21 March 2014 Frequency-selective quantification of skin perfusion behavior during allergic testing using photoplethysmography imaging
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Diagnosis of allergic immediate-type reactions is dependent on the visual assessment of the attending physician. With our novel non-obtrusive, camera-based photoplethysmography imaging (PPGI) setup, perfusion in the allergic testing area can be quantified and results displayed with spatial resolution in functional mappings. Thereby, each PPGI camera pixel can be assumed to be a classical (skin-based) reflective mode PPG sensor. An algorithm for post-processing of collected PPGI video sequences was developed to transfer black-and-white PPGI images into virtual 3D perfusion maps. For the first time, frequency selected perfusion quantification was assessed. For the presented evaluation, PPGI data from our clinical study were used [1]. For this purpose, different concentrations of histamine dilutions were administered to 27 healthy volunteers. Our results show clear trends in an increase in heartbeat synchronous perfusion rhythms and, simultaneously, a decrease of lower frequency vasomotor rhythms in these areas. These results, published for the first time, allow new insight into the distribution of skin perfusion dynamics and demonstrate the intuitive clinical usability of the proposed system.
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Nikolai Blanik, Nikolai Blanik, Claudia Blazek, Claudia Blazek, Carina Pereira, Carina Pereira, Vladimir Blazek, Vladimir Blazek, Steffen Leonhardt, Steffen Leonhardt, "Frequency-selective quantification of skin perfusion behavior during allergic testing using photoplethysmography imaging", Proc. SPIE 9034, Medical Imaging 2014: Image Processing, 903429 (21 March 2014); doi: 10.1117/12.2043567; https://doi.org/10.1117/12.2043567

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