Accurate, fully-automated registration of coronary arteries for volumetric CT digital subtraction angiography

Marco Razeto; Brian Mohr; Kazumasa Arakita; Joanne D. Schuijf; Andreas Fuchs; J. Tobias Kühl; Marcus Y. Chen; Klaus F. Kofoed

doi:10.1117/12.2042775

21 March 2014 Accurate, fully-automated registration of coronary arteries for volumetric CT digital subtraction angiography

Marco Razeto, Brian Mohr, Kazumasa Arakita, Joanne D. Schuijf, Andreas Fuchs, J. Tobias Kühl, Marcus Y. Chen, Klaus F. Kofoed

Author Affiliations +

Proceedings Volume 9034, Medical Imaging 2014: Image Processing; 90343F (2014) https://doi.org/10.1117/12.2042775
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

Diagnosis of coronary artery disease with Coronary Computed Tomography Angiography (CCTA) is complicated by the presence of signi cant calci cation or stents. Volumetric CT Digital Subtraction Angiography (CTDSA) has recently been shown to be e ective at overcoming these limitations. Precise registration of structures is essential as any misalignment can produce artifacts potentially inhibiting clinical interpretation of the data. The fully-automated registration method described in this paper addresses the problem by combining a dense deformation eld with rigid-body transformations where calci cations/stents are present. The method contains non-rigid and rigid components. Non-rigid registration recovers the majority of motion artifacts and produces a dense deformation eld valid over the entire scan domain. Discrete domains are identi ed in which rigid registrations very accurately align each calci cation/stent. These rigid-body transformations are combined within the immediate area of the deformation eld using a distance transform to minimize distortion of the surrounding tissue. A recent interim analysis of a clinical feasibility study evaluated reader con dence and diagnostic accuracy in conventional CCTA and CTDSA registered using this method. Conventional invasive coronary angiography was used as the reference. The study included 27 patients scanned with a second-generation 320-row CT detector in which 41 lesions were identi ed. Compared to conventional CCTA, CTDSA improved reader con dence in 13/36 (36%) of segments with severe calci cation and 3/5 (60%) of segments with coronary stents. Also, the false positive rate of CTDSA was reduced compared to conventional CCTA from 18% (24/130) to 14% (19/130).

Citation Download Citation

Marco Razeto, Brian Mohr, Kazumasa Arakita, Joanne D. Schuijf, Andreas Fuchs, J. Tobias Kühl, Marcus Y. Chen, and Klaus F. Kofoed "Accurate, fully-automated registration of coronary arteries for volumetric CT digital subtraction angiography", Proc. SPIE 9034, Medical Imaging 2014: Image Processing, 90343F (21 March 2014); https://doi.org/10.1117/12.2042775

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available