21 March 2014 Surface-based reconstruction and diffusion MRI in the assessment of gray and white matter damage in multiple sclerosis
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Abstract
Despite advances in the application of nonconventional MRI techniques in furthering the understanding of multiple sclerosis pathogenic mechanisms, there are still many unanswered questions, such as the relationship between gray and white matter damage. We applied a combination of advanced surface-based reconstruction and diffusion tensor imaging techniques to address this issue. We found significant relationships between white matter tract integrity indices and corresponding cortical structures. Our results suggest a direct link between damage in white and gray matter and contribute to the notion of gray matter loss relating to clinical disability.
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Matteo Caffini, Niels Bergsland, Marcella Laganà, Eleonora Tavazzi, Paola Tortorella, Marco Rovaris, Giuseppe Baselli, "Surface-based reconstruction and diffusion MRI in the assessment of gray and white matter damage in multiple sclerosis", Proc. SPIE 9034, Medical Imaging 2014: Image Processing, 90343V (21 March 2014); doi: 10.1117/12.2043268; https://doi.org/10.1117/12.2043268
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