Breast density and parenchymal texture measures as potential risk factors for estrogen-receptor positive breast cancer

Brad M. Keller; Jinbo Chen; Emily F. Conant; Despina Kontos

doi:10.1117/12.2043710

27 March 2014 Breast density and parenchymal texture measures as potential risk factors for estrogen-receptor positive breast cancer

Brad M. Keller, Jinbo Chen, Emily F. Conant, Despina Kontos

Author Affiliations +

Proceedings Volume 9035, Medical Imaging 2014: Computer-Aided Diagnosis; 90351D (2014) https://doi.org/10.1117/12.2043710
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

Accurate assessment of a woman’s risk to develop specific subtypes of breast cancer is critical for appropriate utilization of chemopreventative measures, such as with tamoxifen in preventing estrogen-receptor positive breast cancer. In this context, we investigate quantitative measures of breast density and parenchymal texture, measures of glandular tissue content and tissue structure, as risk factors for estrogen-receptor positive (ER+) breast cancer. Mediolateral oblique (MLO) view digital mammograms of the contralateral breast from 106 women with unilateral invasive breast cancer were retrospectively analyzed. Breast density and parenchymal texture were analyzed via fully-automated software. Logistic regression with feature selection and was performed to predict ER+ versus ER- cancer status. A combined model considering all imaging measures extracted was compared to baseline models consisting of density-alone and texture-alone features. Area under the curve (AUC) of the receiver operating characteristic (ROC) and Delong’s test were used to compare the models’ discriminatory capacity for receptor status. The density-alone model had a discriminatory capacity of 0.62 AUC (p=0.05). The texture-alone model had a higher discriminatory capacity of 0.70 AUC (p=0.001), which was not significantly different compared to the density-alone model (p=0.37). In contrast the combined density-texture logistic regression model had a discriminatory capacity of 0.82 AUC (p<0.001), which was statistically significantly higher than both the density-alone (p<0.001) and texture-alone regression models (p=0.04). The combination of breast density and texture measures may have the potential to identify women specifically at risk for estrogen-receptor positive breast cancer and could be useful in triaging women into appropriate risk-reduction strategies.

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Brad M. Keller, Jinbo Chen, Emily F. Conant, and Despina Kontos "Breast density and parenchymal texture measures as potential risk factors for estrogen-receptor positive breast cancer", Proc. SPIE 9035, Medical Imaging 2014: Computer-Aided Diagnosis, 90351D (27 March 2014); https://doi.org/10.1117/12.2043710

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