13 March 2014 Opto-acoustic breast imaging with co-registered ultrasound
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Abstract
We present results from a recent study involving the ImagioTM breast imaging system, which produces fused real-time two-dimensional color-coded opto-acoustic (OA) images that are co-registered and temporally inter- leaved with real-time gray scale ultrasound using a specialized duplex handheld probe. The use of dual optical wavelengths provides functional blood map images of breast tissue and tumors displayed with high contrast based on total hemoglobin and oxygen saturation of the blood. This provides functional diagnostic information pertaining to tumor metabolism. OA also shows morphologic information about tumor neo-vascularity that is complementary to the morphological information obtained with conventional gray scale ultrasound. This fusion technology conveniently enables real-time analysis of the functional opto-acoustic features of lesions detected by readers familiar with anatomical gray scale ultrasound. We demonstrate co-registered opto-acoustic and ultrasonic images of malignant and benign tumors from a recent clinical study that provide new insight into the function of tumors in-vivo. Results from the Feasibility Study show preliminary evidence that the technology may have the capability to improve characterization of benign and malignant breast masses over conventional diagnostic breast ultrasound alone and to improve overall accuracy of breast mass diagnosis. In particular, OA improved speci city over that of conventional diagnostic ultrasound, which could potentially reduce the number of negative biopsies performed without missing cancers.
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Jason Zalev, Jason Zalev, Bryan Clingman, Bryan Clingman, Don Herzog, Don Herzog, Tom Miller, Tom Miller, A. Thomas Stavros, A. Thomas Stavros, Alexander Oraevsky, Alexander Oraevsky, Kenneth Kist, Kenneth Kist, N. Carol Dornbluth, N. Carol Dornbluth, Pamela Otto, Pamela Otto, } "Opto-acoustic breast imaging with co-registered ultrasound", Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 90381J (13 March 2014); doi: 10.1117/12.2043050; https://doi.org/10.1117/12.2043050
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