9 April 2014 Mapping of ApoE4 related white matter damage using diffusion MRI
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Abstract
ApoliopoproteinE Ɛ4 (ApoE-Ɛ4) polymorphism is the most well known genetic risk factor for developing Alzheimers Disease. The exact mechanism through which ApoE 4 increases AD risk is not fully known, but may be related to decreased clearance and increased oligomerization of Aβ. By making measurements of white matter integrity via diffusion MR and correlating the metrics in a voxel-based statistical analysis with ApoE-Ɛ4 genotype (whilst controlling for vascular risk factor, gender, cognitive status and age) we are able to identify changes in white matter associated with carrying an ApoE Ɛ4 allele. We found potentially significant regions (Puncorrected < 0:05) near the hippocampus and the posterior cingulum that were independent of voxels that correlated with age or clinical dementia rating (CDR) status suggesting that ApoE may affect cognitive decline via a pathway in dependent of normal aging and acute insults that can be measured by CDR and Framingham Coronary Risk Score (FCRS).
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Sinchai Tsao, Sinchai Tsao, Niharika Gajawelli, Niharika Gajawelli, Darryl H. Hwang, Darryl H. Hwang, Stephen Kriger, Stephen Kriger, Meng Law, Meng Law, Helena Chui, Helena Chui, Michael Weiner, Michael Weiner, Natasha Lepore, Natasha Lepore, } "Mapping of ApoE4 related white matter damage using diffusion MRI", Proc. SPIE 9039, Medical Imaging 2014: PACS and Imaging Informatics: Next Generation and Innovations, 90390H (9 April 2014); doi: 10.1117/12.2043925; https://doi.org/10.1117/12.2043925
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