20 March 2014 Born-ratio type data normalization improves quantitation in photoacoustic tomography
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In this report, we present a Born-ratio type of data normalization for reconstruction of initial acoustic pressure distribution in photoacoustic tomography (PAT). The normalized Born-ratio type of data is obtained as a ratio of photoacoustic pressure obtained with tissue sample in a coupling medium to the one obtained using purely coupling medium. It is shown that this type of data normalization improves the quantitation (intrinsic contrast) of the reconstructed images in comparison to the traditional techniques (unnormalized) that are currently available in PAT. Studies are carried out using various tissue samples. The robustness of the proposed method is studied at various noise levels added to the collected data. The improvement in quantitation can enable accurate estimation of pathophysiological parameter (optical absorption coefficient, μa) of tissue sample under investigation leading to better sensitivity in PAT.
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M. Suheshkumar Singh, M. Suheshkumar Singh, Phaneendra K. Yalavarthy, Phaneendra K. Yalavarthy, "Born-ratio type data normalization improves quantitation in photoacoustic tomography", Proc. SPIE 9040, Medical Imaging 2014: Ultrasonic Imaging and Tomography, 90401T (20 March 2014); doi: 10.1117/12.2035213; https://doi.org/10.1117/12.2035213

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