Argon Ion Laser Induced Tissue Fluorescence: Clinical Spectroscopic Studies

R. Cothren; T. Kolubayev; B. T. Kjellstrom M.D.; R. Richards-Kortum; B. Healy M.D.; N. Ratliff M.D.; G. Engelmann; F. Loop M.D.; J. R. Kramer M.D.; C. Kittrell

doi:10.1117/12.945300

21 June 1988 Argon Ion Laser Induced Tissue Fluorescence: Clinical Spectroscopic Studies

R. Cothren, T. Kolubayev, B. T. Kjellstrom M.D., R. Richards-Kortum, B. Healy M.D., N. Ratliff M.D., G. Engelmann, F. Loop M.D., J. R. Kramer M.D., C. Kittrell

Author Affiliations +

Proceedings Volume 0906, Optical Fibers in Medicine III; (1988) https://doi.org/10.1117/12.945300
Event: 1988 Los Angeles Symposium: O-E/LASE '88, 1988, Los Angeles, CA, United States

Abstract

In conjunction with our project in laser angiosurgery, our group has demonstrated that laser-induced auto-fluorescence can be a reliable means of distinguishing normal artery from atherosclerotic plaque. Recently a number of groups have become interested in this technique as a means of directing ablation of arterial obstructions in vivo. However, until now, diagnostic spectroscopy has been conducted almost solely on excised cadaveric tissues. As a result, questions still remain about 1) the validity of correlating cadaveric tissue fluorescence spectra with those collected in vivo, and 2) the ability to collect reliable florescence spectra from a subject as dynamic as a living patient.

Citation Download Citation

R. Cothren, T. Kolubayev, B. T. Kjellstrom M.D., R. Richards-Kortum, B. Healy M.D., N. Ratliff M.D., G. Engelmann, F. Loop M.D., J. R. Kramer M.D., and C. Kittrell "Argon Ion Laser Induced Tissue Fluorescence: Clinical Spectroscopic Studies", Proc. SPIE 0906, Optical Fibers in Medicine III, (21 June 1988); https://doi.org/10.1117/12.945300

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