28 May 2014 Pulsed excitation system to measure the resonant frequency of magnetoelastic biosensors
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Abstract
An electrical circuit was designed and tested to measure the resonant frequency of micron-scale magnetoelastic (ME) biosensors using a pulsed wave excitation technique. In this circuit, a square pulse current is applied to an excitation coil to excite the vibration of ME biosensors and a pick-up coil is used to sense the ME biosensor’s mechanical vibration and convert it to an electrical output signal. The output signal is filtered and amplified by a custom designed circuit to allow the measurement of the resonant frequency of the ME biosensor from which the detection of specific pathogens can be made. As a proof-in-concept experiment, JRB7 phage-coated ME biosensors were used to detect different concentrations of Bacillus anthracis Sterne strain spores. A statistically significant difference was observed for concentrations of 5 × 102 spore/ml and above.
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Hong Xie, Yating Chai, Shin Horikawa, Howard C. Wikle, Bryan A. Chin, "Pulsed excitation system to measure the resonant frequency of magnetoelastic biosensors", Proc. SPIE 9108, Sensing for Agriculture and Food Quality and Safety VI, 910804 (28 May 2014); doi: 10.1117/12.2049888; https://doi.org/10.1117/12.2049888
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