Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor

S. Holler; V. R. Dantham; D. Keng; V. Kolchenko; Stephen Arnold

doi:10.1117/12.2050222

5 June 2014 Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor

S. Holler, V. R. Dantham, D. Keng, V. Kolchenko, Stephen Arnold

Author Affiliations +

Proceedings Volume 9112, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV; 911217 (2014) https://doi.org/10.1117/12.2050222
Event: SPIE Sensing Technology + Applications, 2014, Baltimore, MD, United States

Abstract

The reactive sensing principle applied to hybrid plasmonic whispering gallery mode biosensor has recently demonstrated detection of individual protein cancer markers. The rough surface of a gold nanoparticle affixed to the resonator surface acts like a nanoscopic antenna, significantly boosts the local electric field within the cavity mode. Adsorption of a target protein onto this nanoscopic antenna results in an enhanced response of the resonator system to the binding event. We have demonstrated detection of individual protein molecules (66 kDa) with good signal-to-noise (S/N > 10), and project that detection of proteins as small as 5 kDa are possible.

Citation Download Citation

S. Holler, V. R. Dantham, D. Keng, V. Kolchenko, and Stephen Arnold "Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor", Proc. SPIE 9112, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV, 911217 (5 June 2014); https://doi.org/10.1117/12.2050222

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