8 May 2014 Towards free-hand implementation of OCT elastography: displacement-based approaches versus correlation-stability ones
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In this report, we present a comparative discussion of a recently proposed method of elastographic mapping based on comparison of correlation stability (CS) of different parts of sequentially obtained OCT images of the strained tissue and more conventional correlation approaches to elastographic mapping based on the initial reconstruction of the displacement field. The performed study is based on numerical simulations of speckle patterns generated by reproducing main features of image formation in real OCT scanners. Distortions of such speckle patterns caused by either translational motion of the studied sample or its straining are also incorporated in the developed simulation method. Furthermore, both purely geometrical image distortions and the effects of speckle blinking and boiling are incorporated in the used approach. We demonstrate that properly made correlation processing makes it possible to visualize the differences in the local strains without the necessity of applying error-sensitive procedures of numerical differentiation. Different role of the ratio between the coherence length and the optical wavelength for different variants of correlation based elastographic imaging is discussed. We argue that the proposed CS approach opens attractive possibilities for implementation of elastographic mapping in OCT in free-hand mode.
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Vladimir Y. Zaitsev, Vladimir Y. Zaitsev, Lev A. Matveev, Lev A. Matveev, Alexandr L. Matveyev, Alexandr L. Matveyev, Grigory V. Gelikonov, Grigory V. Gelikonov, Valentin M. Gelikonov, Valentin M. Gelikonov, "Towards free-hand implementation of OCT elastography: displacement-based approaches versus correlation-stability ones", Proc. SPIE 9129, Biophotonics: Photonic Solutions for Better Health Care IV, 91290J (8 May 2014); doi: 10.1117/12.2052518; https://doi.org/10.1117/12.2052518

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