8 May 2014 Advances in tumor diagnosis using OCT and Raman spectroscopy
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Abstract
Complex investigation of malignant tumors was performed with combined optical coherence tomography (OCT) and Raman spectroscopy (RS) setup: 22 ex vivo lung tissue samples and 23 in vivo experiments with skin tumors. It was shown that combined RS-OCT unit may be used for precise tissue morphology visualization with simultaneous tumor type determination (BCC, malignant melanoma of skin tissues, adenocarcinoma and squamous cell carcinoma of lung). Fast RS phase method for skin and lung tumors identification was proposed. It is based on alteration of Raman spectral intensity in 1300-1340, 1440-1460 and 1640-1680 cm-1 bands for healthy and malignant tissue. Complex method could identify: malignant melanoma with 88.9% sensitivity and 87.8% specificity; adenocarcinoma with 100% sensitivity and 81.5% specificity; squamous cell carcinomas with 90.9% sensitivity and 77.8% specificity.
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V. P. Zakharov, I. A. Bratchenko, S. V. Kozlov, A. A. Moryatov, D. V. Kornilin, O. O. Myakinin, D. N. Artemyev, "Advances in tumor diagnosis using OCT and Raman spectroscopy", Proc. SPIE 9129, Biophotonics: Photonic Solutions for Better Health Care IV, 91290L (8 May 2014); doi: 10.1117/12.2052145; https://doi.org/10.1117/12.2052145
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