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8 May 2014 Is there a stimulation of blood microcirculation at low level laser irradiation
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In 1980-2000 besides the laser surgery an intensive evolution of Low Level Laser Therapy (LLLT) had started in medicine, especially in Russia as well as in several other East-European countries. At the same time the biophysical mechanisms of LLLT are still the subject of disputes. One of the most popular clinical effects at Low Level Laser Irradiation (LLLI) being mentioned in medical publications for justification of the LLLT healing outcome is a stimulation of blood microcirculation in irradiated area. It was declared a priori at a dawn of LLLT and is now a basis of medical interpretation of healing mechanisms of LLLT at least in Russia. But in past 20 years a lot of investigation was carried out on optical registration of microhaemodynamic parameters in vivo as well as a number of noninvasive diagnostic tools was created for that. So, today it is possible to experimentally check the blood microcirculation stimulation hypothesis. Our study was aimed on that during the past 10 years. The most precision and accurate experiments we have carried out recently using simultaneously three different noninvasive diagnostic techniques: Laser Doppler Flowmetry, Tissue Reflectance Oximetry and Infrared Thermography. All these methods didn’t confirm the effect on the blood microcirculation stimulation in skin or mucosa at irradiation with the power density below 50 mW/cm2 and irradiation time up to 5-6 minutes. Above this threshold the heating on 0,8…1 °C of tissue in the field of irradiation and the corresponding synchronous increase of all parameters of microhemodynamics were observed.
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Dmitry Rogatkin and Andrey Dunaev "Is there a stimulation of blood microcirculation at low level laser irradiation", Proc. SPIE 9129, Biophotonics: Photonic Solutions for Better Health Care IV, 912922 (8 May 2014);

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