8 May 2014 Clinical measurements analysis of multi-spectral photoplethysmograph biosensors
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The developed portable multi-spectral photoplethysmograph (MS-PPG) optical biosensor device, intended for analysis of peripheral blood volume pulsations at different vascular depths, has been clinically verified. Multi-spectral monitoring was performed by means of a four – wavelengths (454 nm, 519 nm, 632 nm and 888 nm) light emitted diodes and photodiode with multi-channel signal output processing. Two such sensors can be operated in parallel and imposed on the patient’s skin. The clinical measurements confirmed ability to detect PPG signals at four wavelengths simultaneously and to record temporal differences in the signal shapes (corresponding to different penetration depths) in normal and pathological skin. This study analyzed wavelengths relations between systole and diastole peak difference at various tissue depths in normal and pathological skin. The difference between parameters of healthy and pathological skin at various skin depths could be explain by oxy- and deoxyhemoglobin dominance at different wavelengths operated in sensor. The proposed methodology and potential clinical applications in dermatology for skin assessment are discussed.
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Lasma Asare, Lasma Asare, Edgars Kviesis-Kipge, Edgars Kviesis-Kipge, Janis Spigulis, Janis Spigulis, "Clinical measurements analysis of multi-spectral photoplethysmograph biosensors", Proc. SPIE 9129, Biophotonics: Photonic Solutions for Better Health Care IV, 912933 (8 May 2014); doi: 10.1117/12.2052254; https://doi.org/10.1117/12.2052254

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