KAGRA is a unique gravitational wave telescope with its location underground and use of cryogenic mirrors. Safety management plays an important role for secure development and operation of such a unique and large facility. Based on relevant law in Japan, Labor Standard Act and Industrial Safety and Health Law, various countermeasures are mandated to avoid foreseeable accidents and diseases. In addition to the usual safety management of hazardous materials, such as cranes, organic solvents, lasers, there are specific safety issues in the tunnel. Prevention of collapse, flood, and fire accidents are the most critical issues for the underground facility. Ventilation is also important for prevention of air pollution by carbon monoxide, carbon dioxide, organic solvents and radon. Oxygen deficiency should also be prevented.