Using micro and nanofluidics with surface enhanced Raman spectroscopy for in vitro blood based biomarker detection

Gerard L Coté; Jun Kameoka; Haley Marks

doi:10.1117/12.2065418

19 May 2014 Using micro and nanofluidics with surface enhanced Raman spectroscopy for in vitro blood based biomarker detection

Gerard L Coté, Jun Kameoka, Haley Marks

Author Affiliations +

Proceedings Volume 9155, Translational Biophotonics; 91550E (2014) https://doi.org/10.1117/12.2065418
Event: SPIE Translational Biophotonics, 2014, Houston, Texas, United States

Abstract

In this presentation we will discuss the development of a point-of-care optofluidic device that uses gold nanoparticlebased surface enhanced Raman spectroscopy (SERS) for detection of blood biomarkers. SERS approaches have been successfully used for detection of analytes due to the large enhancements provided by the interaction between the light, gold particles, and analyte. However, SERS approaches developed for use to accurately quantify an analyte have suffered from a lack of repeatability. We will describe our SERS optofluidic device with functionalized nanoparticles that helps to overcome these problems and will show results with a focus on blood cardiac biomarkers.

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Gerard L Coté, Jun Kameoka, and Haley Marks "Using micro and nanofluidics with surface enhanced Raman spectroscopy for in vitro blood based biomarker detection", Proc. SPIE 9155, Translational Biophotonics, 91550E (19 May 2014); https://doi.org/10.1117/12.2065418

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KEYWORDS

Surface enhanced Raman spectroscopy

Blood

Raman spectroscopy

Gold

Molecules

Point-of-care devices

Nanoparticles

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