Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes

John C. Rasmussen; Funda Meric-Berstam; Savitri Krishnamurthy M.D.; I-Chih Tan; Banghe Zhu; Jamie L. Wagner; Gildy V. Babiera; Elizabeth A. Mittendorf; Eva M. Sevick-Muraca

doi:10.1117/12.2057640

19 May 2014 Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes

John C. Rasmussen, Funda Meric-Berstam, Savitri Krishnamurthy M.D., I-Chih Tan, Banghe Zhu, Jamie L. Wagner, Gildy V. Babiera, Elizabeth A. Mittendorf, Eva M. Sevick-Muraca

Author Affiliations +

Proceedings Volume 9155, Translational Biophotonics; 91550O (2014) https://doi.org/10.1117/12.2057640
Event: SPIE Translational Biophotonics, 2014, Houston, Texas, United States

Abstract

In this proof-of-concept study we seek to demonstrate the delivery of fluorescent contrast agent to the tumor-draining lymph node basin following intraparenchymal breast injections and intradermal arm injection of micrograms of indocyanine green in 20 breast cancer patients undergoing complete axillary lymph node dissection. Individual lymph nodes were assessed ex vivo for presence of fluorescent signal. In all, 88% of tumor-negative lymph nodes and 81% of tumor-positive lymph nodes were fluorescent. These results indicate that future studies utilizing targeted fluorescent contrast agents may demonstrate improved surgical and therapeutic intervention.

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John C. Rasmussen, Funda Meric-Berstam, Savitri Krishnamurthy M.D., I-Chih Tan, Banghe Zhu, Jamie L. Wagner, Gildy V. Babiera, Elizabeth A. Mittendorf, and Eva M. Sevick-Muraca "Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes", Proc. SPIE 9155, Translational Biophotonics, 91550O (19 May 2014); https://doi.org/10.1117/12.2057640

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