Wide-field endoscopic fluorescence imaging for gastrointestinal tumor detection with glucose analogue

Yun He; Yawei Qu; Jing Bai; Haifeng Liu

doi:10.1117/12.2057696

19 May 2014 Wide-field endoscopic fluorescence imaging for gastrointestinal tumor detection with glucose analogue

Yun He, Yawei Qu, Jing Bai, Haifeng Liu

Proceedings Volume 9155, Translational Biophotonics; 91550R (2014) https://doi.org/10.1117/12.2057696
Event: SPIE Translational Biophotonics, 2014, Houston, Texas, United States

Abstract

The lack of functional information and targeted imaging in conventional white-light endoscopy leads to a high miss-rate of gastrointestinal tumor. The combination of near-infrared fluorescence imaging and endoscopy presents a promising approach. Here we introduce a new endoscopy method employing a home-made flexible wide-field epi-fluorescence endoscope, that can be inserted through the biopsy channel of a gastrointestinal endoscope, with the glucose analogue 2- DeoxyGlucosone as the near-infrared fluorescent probe. System characterization indicates a good sensitivity and linearity over a large field of view. Its capability of tumor identification and location is demonstrated with in-vivo imaging of xenografted tumor model.

Citation Download Citation

Yun He, Yawei Qu, Jing Bai, and Haifeng Liu "Wide-field endoscopic fluorescence imaging for gastrointestinal tumor detection with glucose analogue", Proc. SPIE 9155, Translational Biophotonics, 91550R (19 May 2014); https://doi.org/10.1117/12.2057696

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