19 May 2014 Wide-field endoscopic fluorescence imaging for gastrointestinal tumor detection with glucose analogue
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Abstract
The lack of functional information and targeted imaging in conventional white-light endoscopy leads to a high miss-rate of gastrointestinal tumor. The combination of near-infrared fluorescence imaging and endoscopy presents a promising approach. Here we introduce a new endoscopy method employing a home-made flexible wide-field epi-fluorescence endoscope, that can be inserted through the biopsy channel of a gastrointestinal endoscope, with the glucose analogue 2- DeoxyGlucosone as the near-infrared fluorescent probe. System characterization indicates a good sensitivity and linearity over a large field of view. Its capability of tumor identification and location is demonstrated with in-vivo imaging of xenografted tumor model.
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Yun He, Yun He, Yawei Qu, Yawei Qu, Jing Bai, Jing Bai, Haifeng Liu, Haifeng Liu, "Wide-field endoscopic fluorescence imaging for gastrointestinal tumor detection with glucose analogue", Proc. SPIE 9155, Translational Biophotonics, 91550R (19 May 2014); doi: 10.1117/12.2057696; https://doi.org/10.1117/12.2057696
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