Performance evaluation of integrating detectors for near-infrared fluorescence molecular imaging

Banghe Zhu; John C. Rasmussen; Eva M. Sevick-Muraca

doi:10.1117/12.2057815

19 May 2014 Performance evaluation of integrating detectors for near-infrared fluorescence molecular imaging

Banghe Zhu, John C. Rasmussen, Eva M. Sevick-Muraca

Proceedings Volume 9155, Translational Biophotonics; 91551F (2014) https://doi.org/10.1117/12.2057815
Event: SPIE Translational Biophotonics, 2014, Houston, Texas, United States

Abstract

Although there has been a plethora of devices advanced for clinical translation, there has been no standards to compare and determine the optical device for fluorescence molecular imaging. In this work, we compare different CCD configurations using a solid phantom developed to mimic pM - fM concentrations of near-infrared fluorescent dyes in tissues. Our results show that intensified CCD systems (ICCDs) offer greater contrast at larger signal-tonoise ratios (SNRs) in comparison to their un-intensified CCD systems operated at clinically reasonable, sub-second acquisition times. Furthermore, we compared our investigational ICCD device to the commercial NOVADAQ SPY system, demonstrating different performance in both SNR and contrast.

Citation Download Citation

Banghe Zhu, John C. Rasmussen, and Eva M. Sevick-Muraca "Performance evaluation of integrating detectors for near-infrared fluorescence molecular imaging ", Proc. SPIE 9155, Translational Biophotonics, 91551F (19 May 2014); https://doi.org/10.1117/12.2057815

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