19 May 2014 Performance evaluation of fluorescence tomography in a Siemens Inveon multimodality scanner
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Abstract
A tri-modal (PET/CT/Optical) small animal tomographic imaging system was developed by integrating our advanced non-contact intensified CCD (ICCD) frequency-domain fluorescence imaging components into a Siemens Inveon scanner. We performed a performance evaluation of the developed imaging system by using the developed regularization-free high-order radiative-transfer-based reconstruction algorithm and custom solid phantoms. Our results show that frequency-domain photon migration (FDPM) fluorescence tomography can achieve better tomographic images with less artifacts and more precise fluorescent source localization compared to the continuous-wave counterpart. The developed multimodal tomographic imaging system provides a powerful tool for translational biomedical research.
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Yujie Lu, Yujie Lu, Chinmay Darne, Chinmay Darne, I-Chih Tan, I-Chih Tan, Banghe Zhu, Banghe Zhu, John Rasmussen, John Rasmussen, Eva M. Sevick-Muraca, Eva M. Sevick-Muraca, } "Performance evaluation of fluorescence tomography in a Siemens Inveon multimodality scanner", Proc. SPIE 9155, Translational Biophotonics, 91551H (19 May 2014); doi: 10.1117/12.2057818; https://doi.org/10.1117/12.2057818
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