19 May 2014 Bone optical spectroscopy for the measurement of hemoglobin content
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Osteoporosis is a common side effect of spinal cord injuries. Blood perfusion in the bone provides an indication of bone health and may help to evaluate therapies addressing bone loss. Current methods for measuring blood perfusion of bone use dyes and ionizing radiation, and yield qualitative results. We present a device capable of measuring blood oxygenation in the tibia. The device illuminates the skin directly over the tibia with a white light source and measures the diffusely reflected light in the near infrared spectrum. Multiple source-detector distances are utilized so that the blood perfusion in skin and bone may be differentiated.
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Joseph L Hollmann, Joseph L Hollmann, Paula Arambel, Paula Arambel, Judith Piet, Judith Piet, Sandra Shefelbine, Sandra Shefelbine, Stacey Markovic, Stacey Markovic, Mark Niedre, Mark Niedre, Charles A. DiMarzio, Charles A. DiMarzio, "Bone optical spectroscopy for the measurement of hemoglobin content", Proc. SPIE 9155, Translational Biophotonics, 91551L (19 May 2014); doi: 10.1117/12.2060716; https://doi.org/10.1117/12.2060716

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