2 June 2014 Nonadiabatic tapered optical fiber biosensor for detection of potassium ion using DNA aptamer in neural application
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Proceedings Volume 9157, 23rd International Conference on Optical Fibre Sensors; 91574K (2014) https://doi.org/10.1117/12.2059036
Event: OFS2014 23rd International Conference on Optical Fiber Sensors, 2014, Santander, Spain
Abstract
A single-mode nonadiabatic tapered optical fiber (NATOF) biosensor based on ssDNA aptamer for detection of potassium ion (K+) was developed. Upon binding to K+, the G-rich single-stranded DNA can fold into the G-quadruplex structure, thus allowing the formation of G-quadruplex complex after incubation with K+ which is led to changing in refractive index (RI). Under optimum conditions, the wavelength shift was proportional to the concentration of K+ in the range of 10 ×10-4 to 2×10-2 mM. A detection limit of 4.5×10-4 was achieved. Moreover, this method was able to detect K+ with high selectivity in the presence of Na+ ion of biological fluids.
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M. I. Zibaii, H. Latifi, A. Asadollahi, "Nonadiabatic tapered optical fiber biosensor for detection of potassium ion using DNA aptamer in neural application", Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 91574K (2 June 2014); doi: 10.1117/12.2059036; https://doi.org/10.1117/12.2059036
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