16 September 2014 Optical tweezers for free-solution label-free single bio-molecule studies
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Nanoaperture based trapping has developed as a significant tool among the various optical tweezer systems for trapping of very small particles down to the single nanometer range. The double nanohole aperture based trap provides a method for efficient, highly-sensitive, label-free, low-cost, free-solution single molecule trapping and detection. We use the double nanohole tweezer to understand biomolecular phenomena like protein unfolding, binding, structural conformation of DNA, protein-DNA interactions, and protein small molecule interactions.
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Abhay Kotnala, Abhay Kotnala, Ahmed A. Al-Balushi, Ahmed A. Al-Balushi, Reuven Gordon, Reuven Gordon, "Optical tweezers for free-solution label-free single bio-molecule studies", Proc. SPIE 9164, Optical Trapping and Optical Micromanipulation XI, 916418 (16 September 2014); doi: 10.1117/12.2062051; https://doi.org/10.1117/12.2062051

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